IMPACT OF FEEDING MALE RATS F 2 WITH DIFFERENT DOSES
OF GERMANIUM CITRATE ON THE CONTENT
OF MICROELEMENTS IN THE TISSUES AND ORGANS
R. S. Fedoruk 1
, U. I. Tesarivska 2
, M. I. Khrabko 1
, M. M.
, H. H. Denys 1
Institute of Animal Biology, NAAS,
38, V. Stusa Str., Lviv, Ukraine, 79034
SCIVP of veterinary medical products and feed additives,
11, Donetska Str., Lviv, Ukraine, 79019
Received on August 06, 2018 / Received October 04, 2018 / Accepted November 21, 2018
Aim. To determine the impact of the dose of germanium citrate on the distribution of Fe, Zn, Cu,
Co, Mn in
tissues and organs of male F 2 rats. Methods. Physiological, biochemical, clinical, statistical.
Results. It was
established that there were changes in the content of Fe, Zn, Cu, Co, Mn in soft tissues and their
in liver, kidneys and lungs of male F 2 rats. It was demonstrated that these changes were mostly
by organ-tissue specifi cities of functioning of some physiological systems of the organism, and
ed – by the dose of germanium (10, 20 and 200 μg/kg of bodyweight). More vividly expressed changes
content of these elements were established for kidneys at the effect of all the applied doses, and
ed – for liver and lungs. A positive impact of germanium citrate on the content of Cu, Co, Mn and
Zn in the
muscle tissues was determined at the effect of 10, 20 and 200 μg Ge, and as for Fe – 20 and 200 μg.
differences in the weight of liver, kidneys and lungs of rats of experimental and control groups
which eliminated the intergroup differences in the absolute content of the investigated
microelements in liver,
kidneys and lungs. The mentioned differences were more expressed for the absolute content of Cu in
Mn – in kidneys and lungs. Conclusions. Long-term introduction of germanium citrate into the
rats of generation F 2 with water in the amount of 10, 20 and 200 μg Ge/kg of the bodyweight is
by the changes in the content of Cu, Co, Mn, Fe, Zn both per one unit of soft tissue weight and
content in the internal organs. The biological effect of germanium citrate is more expressed in the
dose of 200
μg Ge/kg of the bodyweight, which conditions the increase in the content of Cu and Zn in all the
tissues of rats of this group at the background of the decreased level of Co in liver at the effect
of 20 and 200
μg Ge, and at the effect of all the administered doses in kidneys and lungs. The level of Mn
in the muscle tissues of male F 2 rats at the effect of all the administered doses of Ge, Co 20 and
200 μg, Fe 10
and 20 μg, and Zn 10 and 200 μg Ge, which testifi es to the differences in the regulatory impact of
NGeC on the
level of investigated microelements in the muscle tissues of rats.
germanium citrate, microelements, rats, soft tissues.
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